Appendectomies raise risk of Parkinson’s disease

Our Beloved Family:
Parkinson’s disease along with Alzheimer’s disease is one of the major neurodegenerative disorders that affect people as they age. Unfortunately, rates have been increasing over the last several decades. Identifying things that place us at greater risk for developing the disease is an important step toward reducing new cases and finding a cure. Research has recently shown that one of those risks is having an appendectomy.

Previous studies have revealed that in cases of early onset of Parkinson’s disease the protein alpha synuclein begins to collect in enteric neurons in the gastrointestinal tract. This pathology has led researchers to suspect that the gastrointestinal tract may play a role in the development of Parkinson’s disease. In fact, it has been suspected for quite some time that an appendectomy raises the risk for Parkinson’s disease but no large scale epidemiological study existed to prove the theory, until now.

The Parkinson's Puzzle: Appendectomies raise risk of Parkinson's disease

A recent study1 from Case Western Reserve University examined the medical records of 488,190 patients across 26 U.S. healthcare systems who underwent an appendectomy. Their goal was to discover how many of those patients developed Parkinson’s disease in the six months after their surgery and whether their risk was elevated when compared to those in the general population. Results showed that overall, patients who had an appendectomy more than doubled their risk for developing Parkinson’s disease. For patients between 18 and 64 the risk tripled. The risk was highest for Caucasians and Asians, followed by African Americans. The difference was slightly higher for men than women and increased with age. Researchers also stated that because their study was limited to the six months immediately after having an appendectomy the exact time frame of developing Parkinson’s disease couldn’t be determined because others were probably diagnosed several more months or even years later.

It’s understandable that in an emergency where an appendix has ruptured or is in danger of rupturing that it needs to be removed. However, be wary of any doctor who recommends elective removal of the appendix because of mild symptoms that might be treated with other means. While there are no studies showing how appendicitis can be prevented, it is thought that keeping the digestive tract healthy with a high fiber diet, preferably from vegetables or an organic psyllium supplement, is a good choice. Because appendicitis is caused by an infection it would be a good idea to keep the immune system as strong as possible with a good diet, exercise, and supplements that help the body resist infection like vitamin C, beta-carotene, and zinc.

Love, Light, and Clarity in the Month Ahead,
Dr. Habib Sadeghi and Dr. Sherry Sami

Keep your digestive system healthy with Healing Digest Plus.


  1. 1. Bender, Kenneth, “Appendectomies and the Development of Parkinson’s Disease”, MD Magazine, (May 21, 2019),
Dr. Sadeghi & Dr. Sami
Dr. Habib Sadeghi D.O., is the co-founder of Be Hive of Healing, an integrative health center based in Los Angeles. With more than 15 years of direct patient care, he provides a comprehensive knowledge of revolutionary healing protocols in integrative, osteopathic, anthroposophical, environmental, and family medicine, as well as clinical pharmacology. Through a unique and individualized approach to healthcare that includes evidence-based, Western medical interventions and intuitive Eastern healing modalities, Dr. Sadeghi has been able to achieve astounding results in patient cases that were otherwise deemed hopeless by traditional medicine. Read biography 
Dr. Shahrzad (Sherry) Sami is a dual specialist in pediatric dentistry and orthodontics. She has served as a clinical instructor at the University of California Los Angeles, as part of both the pediatric medicine and dentistry programs, becoming one of the creators of the Children Health Advocacy Training (CHAT) curriculum. Collaborating with pediatricians, Dr. Sami designed one of the few residency training programs that incorporates a whole body approach that includes aspects such as breastfeeding, nutrition and child development. Her practice is based on total body wellness, a philosophy that recognizes the synergistic connection our emotions play in our physical condition. It also emphasizes the correlation of a healthy mouth, jaw and airways with a vibrant, energetic body. Read biography
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